二甲双胍(英语:Metformin)是治疗2型糖尿病个一线药物,特别是针对超重患者。本品属于口服药物,通常呒没明显副作用,常见副作用包含腹泻、恶心、腹痛咾啥,造成低血糖个机会不大。常见商品名格华止库鲁化(Glucophage)。

本品也好用于治疗多囊卵巢综合症,一眼动物实验还发现渠交关别样用场。

  • 完全逆转疼痛产生个认知障碍[1]
  • 作为AMPK激动剂缓解尼古丁戒断反应以协助戒烟[2]
  • 作为AMPK激动剂让抗拒细胞凋亡个肌成纤维细胞增多以逆转肺纤维化[3]
  • 通过提高细胞核里Nrf2转录因子个水平来提高谷胱甘肽过氧化物酶7表达以延缓衰老。[4]
  • 通过抑制肝癌细胞对己糖激酶抑制(饿杀肝癌细胞)个适应性反应(增强葡萄糖氧化磷酸化)来增加细胞死亡並抑制肿瘤增生。[5]

文献 编辑

  1. Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin
  2. Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal
  3. Metformin reverses established lung fibrosis in a bleomycin model
  4. Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
  5. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin